Email : hoda.muddasar@gmail.com

Address : ll-A/27, Action Area II, Newtown, Kolkata, West Bengal 700156

Room No : Faculty Room, 8th Floor, Right Block

Joined : 18/09/2017

Nanobiotechnology is an interdisciplinary research domain that deals with designing, synthesis, and application of particles of sizes ranging between 1-500 nanometres in diameter. Nanoparticles and nanocomposites have wide range of applications in biomedical field that ranges between diagnosis, imaging and therapy. We at NAP LAB, are trying to address the limited bioavailability of the various therapeutic molecules by enhancing the cellular uptake of drug-loaded nanoparticles by surface functionalization of the same. Biopolymers from natural sources are being explored for potential synthesis of biodegradable and biocompatible nanoparticles that has significant drug payload.

Applied phytochemistry is a subject that deals with the extraction, isolation, identification, and application of wide range of compounds from various plant sources. Among the most commonly known phytochemicals is Quinine, an important alkaloid isolated form the bark of cinchona tree, is an important anti-malarial compound. Similarly, there exists a huge trove of potential phytochemicals in diverse plant sources that is influenced by geographical, climatic and seasonal variations. At NAP lab, we try understand the molecular action of mechanism of these phytochemicals with therapeutic potential against various diseases, especially diabetes and cancer. This domain of research contributes to the scientific foundation of various traditional folk medicine, that otherwise lacks modern scientific validation.

Researchers at NAP Lab are expected to broaden their technical skills with techniques such as chromatography, spectroscopy, cell culture handling, molecular biology techniques, and computational biology.

Education

Field of Specialization

Nanobiotechnology

Applied phytochemistry

Courses Taught/Teaching

1. Metabolism and Plant biochemistry

2. Plant physiology

3. Biotechniques and biostatistics

4. Bioinformatics

5. Genetics/Microbial genetics

6. Molecular biology 

Research Area

1. Biopolymer based nanoparticles as therapeutic, theragnostic, and drug delivery system
2. Phytochemicals extraction, identification, and delineation of its molecular mechanism of action against various diseases.
3. Application of nanobiotechnology in agriculture.

Experience

Conference Papers Published

1. Presented a poster on “Influence of stabilizers on production of Disulfiram loaded nanoparticles and their anti-cancer potential” at International Conference, Biomaterials-2014, organized by IIT, New Delhi, in October 2014.

Journal Papers Published

1.  

   Sufi SA, Hoda M, Pajaniradje S, Mukherjee V, Coumar SM, Rajagopalan R. Enhanced drug retention, sustained release, and anti-cancer potential of curcumin and indole-curcumin analog-loaded polysorbate 80-stabilizied PLGA nanoparticles in colon cancer cell line SW480. International Journal of Pharmaceutics. 2020;588:119738. doi:10.1016/j.ijpharm.2020.119738

2. Ahmad I, Hoda M. Molecular mechanisms of action of resveratrol in modulation of diabetic and non-diabetic cardiomyopathy. Pharmacological Research. 2020;161:105112. doi:10.1016/j.phrs.2020.105112

3. Ahmad I, Hoda M. Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of action. Life Sciences. 2020;245:117350. doi:10.1016/j.lfs.2020.11735

4. Hoque M, Safdar Ali, Hoda M (2018) Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus. International Journal of Biological Macromolecules, 118:2237-2244 https://doi.org/10.1016/j.ijbiomac.2018.07.091

5. Hoda M, Cavuturu B, Iqbal S, Shakya G, Rajagopalan R. Disulfiram &   Disulfiram-loaded poly- [lactide-co-glycolic acid] nanoparticles modulate metastatic markers & proteasomal activity in hepatocarcinoma hep3b cell line. (European Journal of Nanomedicine, 2017, AOP, https://doi.org/10.1515/ejnm-2017-0013)

6. Hoda M, Cavuturu B, Sufi SA, Rajagopalan R. Stabilizers Influence Drug-Polymer Interactions and Physiochemical properties of Disulfiram-Loaded PLGA Nanoparticles. (Future Science OA, 2017, https://doi.org/10.4155/fsoa-2017-0091)

7. Shakya G, Balasubramanian S, Hoda M & Rajagopalan R. Inhibition of metastasis and angiogenesis in Hep-2 cells by wheatgrass extract – an in vitro and in silico approach. (Toxicology Mechanisms & Methods, 2017, DOI: 10.1080/15376516.2017.1388460)

8. Hoda M, Pajaniradje S, Shakya G, Mohankumar K, Rajagopalan R. Anti-proliferative and apoptosis-triggering potential of Disulfiram and Disulfiram-loaded Polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line. (Nanomedicine:NBM, 2016;12:1641-1650)

9. Hoda M, Sufi SA, Shakya G, Kumaravel M, Rajagopalan R. Influence of stabilizers on production of disulfiram loaded PLGA nanoparticles and their anti-cancer potential. Therapeutic delivery. 2015;6(1):17-25 

10. Durairaj V, Hoda M, Shakya G, Babu SP, Rajagopalan R. Phytochemical screening and analysis of antioxidant properties of aqueous extract of wheatgrass. Asian Pacific Journal of Tropical Medicine. 2014;7S1:S398-404

11. Shakya G, Durairaj V, Hoda M, Rajagopalan R. RP-HPLC analysis & oxidative stress mediated cytotoxic effect of methanol extract of wheat grass by modulating Nrf2-level in Hep-2 cells. International Journal of  pharma Sciences. 2015;5(1):897-903

12. Shakya G, Manjini S, Hoda M, Rajagopalan R. Hepatoprotective role of kaempferol during alcohol- and �PUFA- Induced oxidative stress. Journal of Basic Clinical Physiology and Pharmacology. 2014;25(1):73-79

13. Rukkumani Rajagopalan, Shakya G, Pajaniradje S, Hoda M, Durairaj V. GC-MS Analysis, In Vitro Antioxidant and Cytotoxic Studies of Wheatgrass Extract. American Journal of Phytomedicine and Clinical Therapeutics. 2014;2(7):877-893

Books Published

Role of Phenolic Phytochemicals in Diabetes Management, 2019, Springer Singapore, ISSN 978-981-13-8996-2; DOI: 10.1007/978-981-13-8997-9 

Hoda, Muddasarul, Hemaiswarya, Shanmugam, Doble, Mukesh

Ph.D. Thesis Guidance

Registered PhD Scholars: 02

Membership Of Learned Societies

• Life Member, Indian Science Congress

Other Notable Activities

 Coordinator; SWAYAM NPTEL Local Chapter for Aliah University